Table 2. Factorial Study on Tumor-Bearing BL/6 Micea.
| 2A AP2-Matrix | |||
|---|---|---|---|
| Factor: AP2-loading (% coligation of AP2) | Factor: Dose [X] | Response (1): Fluorescence intensity (uptake in tumor) | Response (2): Tumor Selectivity (ratio T/NB) |
| 0 | 0.25 | 10.02 | 9.73 |
| 1 | 0.625 | 31.20 | 11.87 |
| 2 | 0.25 | 13.48 | 6.51 |
| 2 | 1 | 148.25 | 15.75 |
| 0 | 1 | 42.66 | 5.13 |
| 2B Combined Matrix | ||||
|---|---|---|---|---|
| Factor: AP2-loading (%AP2 = 2%–X%B6) | Factor: B6 B6-loading (%B6 = 2%–X%AP2) | Factor: Dose [X] | Response (1): Fluorescence intensity (uptake in tumor) | Response (2): Tumor Selectivity (ratio T/NB) |
| 2 | 0 | 0.25 | 13.48 | 6.55 |
| 1 | 1 | 0.625 | 50.39 | 12.17 |
| 0 | 2 | 1 | 69.20 | 10.25 |
| 2 | 0 | 1 | 148.25 | 15.75 |
| 0 | 2 | 0.25 | 2.97 | 6.84 |
a
DoE-matrix which contains factor “loading AP2” or factor “loading AP2, B6”, factor “DoseX”, the response (1) “Fluorescence Intensity” and response tumor (2) “Selectivity”.