TABLE 1.

Characteristics of participants with low Aβ PET and high neocortical tau PET tracer retention

	Participant 1	Participant 2	Participant 3	Participant 4
Age	76	67	68	72
Sex	M	F	M	M
Diagnosis	CU	MCI	MCI	AD
Centiloid	−2.50	1.43	1.82	18.40
APOE	E3/E3	–	E3/E3	E4/E3
Me SUVR	1.14	2.73 a	3.27 a	1.27
Te SUVR	1.37 a	3.59 a	4.01 a	3.04 a
R SUVR	0.96	1.89 a	2.01 a	1.68 a
MTL atrophy b	0	0	2 (1 right, 3 left)	2.5 (2 right, 3 left)
PVWMH c	0	2	10	2
DWMH c	1	2	0	1
MMSE	29	24	24	22
CDR	0	0.5	0.5	1

Abbreviations: AD, Alzheimer's disease; APOE, apolipoprotein E; CDR, Clinical Dementia Rating scale; CU, cognitively unimpaired; DMWHs, deep white matter hyperintensities; MCI, mild cognitive impairment; MMSE, Mini‐Mental State Examination; MTL, mesial temporal lobe; PVMWHs, peri‐ventricular white matter hyperintensities; SUVR, standardized uptake value ratio; Me, mesial temporal; Te, temporo‐parietal; R, rest of brain.

^a  = above the upper bound of the peri‐threshold range for the specified region of interest (ROI).

^b  = average (right and left) mesial temporal lobe atrophy scores, as previously described. ²⁷

^c  = Fazekas’ score for the visual assessment of white matter hyperintensities, as previously described. ²⁸