. 2022 Aug 26;14(1):e12326. doi: 10.1002/dad2.12326

TABLE 2.

Additional biomarker results for participants with low Aβ PET and high neocortical tau PET tracer retention

Biomarker		Participant 1	Participant 2	Participant 3	Participant 4
CSF	CSF Aβ_1‐42	–	386pg/mL (low) ^a	–	–
	CSF p‐tau	–	89pg/mL (high) ^a	–	–
	CSF t‐tau	–	553pg/mL (high) ^a	–	–
Plasma	Plasma Aβ ^b	1.69 (abnormal)	–	–	–
Plasma	Plasma p217+tau ^c	High	–	High	High

^{^a}

= reference range for CSF Aβ_1‐42>656 pg/mL, p‐tau <59 pg/mL, t‐tau <304 pg/mL, where the age‐adjusted reference ranges were generated based on an AIBL healthy control cohort (>60 years). ²⁹ Sample collected was tinged pink, with a red blood cell count of 1600/μL.

^{^b}

= AIBL composite value from a combined immunoprecipitation and mass spectrometry method previously described, ³⁰ a measure validated in the AIBL cohort.

^{^c}

= plasma p217+tau assay was performed on a SIMOA platform, using a method previously described, ³¹ and has been evaluated in the AIBL cohort. ³² Participant 2 did not have a blood sample available for testing.