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Body weight and glucose regulation in DIO mice treated with ETG-5773 for 7 days. (a) Body weight; (b) fasting blood glucose concentrations; (c) fasting serum insulin concentrations. Animals were treated orally twice a day with 15 mg/kg ETG-5773 or with the corresponding vehicle or vehicle in the pair-fed group. * p < 0.05, ** p < 0.01, **** p < 0.0001 as indicated, ns: non-significant. ANOVA mean SD, n = 6.
