Table 1.

In vitro data for the effect of the inhibitor ETG-5773 on cell lines expressing human and mouse transporters.

	[14C] Substrate Uptake			Fatty Acid Synthesis	Cytotoxicity
Cell line	HepG2	HEK293	HEK293	HepG2	HepG2
Species	Human	Mouse	Human	Human	Human
Substrate	Citrate	Citrate	Succinate	Citrate	-
Transporter	NaCT	Nact	NaDC3	NaCT	-
IC50	160 nM	180 nM	>20 µM	1 µM	>50 µM