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. 2022 Aug;72(4):230–242. doi: 10.30802/AALAS-CM-22-000045

Figure 1.

Figure 1.

Representative histopathology of the lung and cecum from a 1.5-y-old, female, C57Bl/6/Foxp3CreERR26tdTomato mouse. (A) Multifocally, peribronchiolar and perivascular spaces are infiltrated by small to moderate clusters of lymphocytes and histiocytes (scale bar = 500 µm). (B) High magnification field shows lymphocytic and histiocytic infiltrates around a bronchiole (scale bar = 100 µm). (C) IHC of the lung demonstrating focal detection of chlamydial MOMP antigen in bronchiolar epithelial cells (scale bars = 100 µm; 20 µm - brown staining in inset). (D) Representative section of normal mucosa and gut-associated lymphoid tissue (GALT) in the cecum with low numbers of luminal T. muris (arrowheads and inset; scale bars = 100 µm). (E) IHC of the cecum demonstrating detection of intracytoplasmic chlamydial inclusions in surface epithelial cells (arrowhead; scale bar = 20 µm). (F) ISH demonstrates positive staining (red) for Cm mRNA within the cecal epithelium (arrowhead) and lumen (arrow; scale bar = 20 µm).