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The biogenesis of snoRNAs and SNHGs. (A). Small nucleolar RNAs (snoRNAs) are mainly located in introns. After splicing and maturation, mature snoRNAs are exported to the nucleolus, where they assist in the modification and processing of rRNA and snRNA. (B). Small nucleolar RNA host genes (SNHGs) are transcribed and act as competing endogenous RNAs (ceRNAs) by antagonizing miRNAs and modulating the translation of target genes.
