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Representative mechanisms of snoRNAs in hematopoietic malignancies. (A). snoRNA ACA11 resulted in accumulated 45S pre-rRNA, promoted proliferation, and increased cell size. (B). SNHG sponged miRNAs and promoted myeloma cell immune evasion. (C). AML1-ETO protein promoted self-renewal of AML cells depending on the interaction between C/D box snoRNA and DDX21. (D). DDX41R525H/- caused dysregulation in hematopoiesis, downregulation of snoRNA expression, and defects in ribosome biogenesis.
