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. 2022 Aug 22;21:175–193. doi: 10.1016/j.bioactmat.2022.08.001

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 5 — Clinical application of hydrogel in mandibular reconstruction. (A) CT image of the mandibular lesion. (B) Tumor specimen. (C) Bioimplant (rhBMP-2/Absorable collage sponge) inserted and covered by titanium mesh (A-C, Copyright © 2011 Alan S. Herford et al. Ref [141]). (D) Another clinical case used absorbable collagen containing rhBMP-2 in the concave area of the titanium mesh. (E) Histology showed a large amount of newly formed bone and bone marrow/connective tissue in the rhBMP-2-containing collagen implanted area (D-E, Copyright © 2022 Elsevier B·V., Ref. [146]).