Figure 3.

Inflammatory response in organs of CVB3/28-infected DBA/2J mice. (A–D) IFN-β, IL-10, TNF-α, and MCP1 levels were measured by ELISA in homogenized organs supernatants of CVB3/28-infected DBA/2J mice and compared to cytokines levels in homogenized organs supernatants of uninfected DBA/2J mice (n = 4 to 5). Data represent mean +/− SEM (Mann–Whitney U test; *: p < 0.05; **: p < 0.01; ***: p < 0.001; ****: p < 0.0001; ns or not specified: non-significant). (E) Positive CD3 and CD68 cells were found in inflammatory foci or infiltrates at 7 DPI only in the heart, pancreas, and liver. They were absent in other organs and in uninfected mice. Original magnification: heart, 200×; pancreas and liver, 400×. DPI: Days Post Infection. UI: Uninfected.