Fig. 1.

Anatomical distribution of primary squamous cell carcinomas arising in patients with different forms of epidermolysis bullosa (EB). Most severe recessive dystrophic EB (RDEB-S) tumours arose over bony prominences, particularly the joints of hands and feet. Dominant dystrophic EB (DDEB) and RDEB- pruriginosa (RDEB-Pru) tumours were more common on the lower legs, particularly the shins. All squamous cell carcinomas in the Kindler EB (KEB) patient arose on the hand. JEB: junctional EB; Int: intermediate; Inv: inversa.