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Indirect comparison between onabotulinumtoxinA and antibodies directed towards the signaling of CGRP. Anti-CGRP mAbs reduce the number of monthly headache days from baseline of 1.94 days and botulinum toxin of 1.86 days [36]. How much reduction the combination of the two treatments can afford is to be discovered. Data are expressed as monthly headache days (MHDs) difference over baseline ± upper/lower limit of confidence interval (CI).
