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[Preprint]. 2022 Aug 19:2022.08.19.504551. [Version 1] doi: 10.1101/2022.08.19.504551

Figure 5. SARS-CoV-2 infection results in substantially reduced mechanical thresholds and a neuropathic transcriptomic landscape in the tDRGs well after viral clearance.

Figure 5.

A) Mechanical thresholds of mock, IAV, and SARS-CoV-2 animals at 28dpi (n=6 per group; **p<0.01, ****p<0.0001 for one-way ANOVA Tukey’s m.c.). B) Volcano plot for 31dpi SARS-CoV-2 tDRG RNA-seq (n=3 per group). Red=p-adj.<0.1, log2FC>0. Blue=p-adj.<0.1, log2FC>0. Green=p-nom.<0.05. C) IPA top 10 canonical pathways (−log10(p-value)>1.3) associated with 31dpi SARS-CoV-2 tDRG DEGs (p-nom.<0.05). D) enrichr DisGENET gateway top 10 diseases associated with 31 dpi SARS-CoV-2 tDRG DEGs (p-nom.<0.05). E) Log2(FC) of select neuronal and inflammatory genes from 31dpi RNA-seq (p-adj.<0.1). F) Positively and negatively enriched cell subtypes associated with 31dpi SARS-CoV-2 tDRG DEGs (GSEA NES>|1.5|; DEG p-adj.<0.1). G) IPA top 15 upstream regulators between 31dpi SARS-CoV-2 tDRG, Striatum, and Thalamus (DEG p-nom.<0.05).