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Schematic diagram of the renin-angiotensin system (RAS). RAS components are indicated in grey while treatments used in the study are indicated by a blue shape. Green arrows indicate promotion while hashed red arrows indicate inhibition. COX2 is cyclooxygenase 2; PRR is prorenin receptor; IGF/IGFR-1 is insulin-like growth factor/insulin-like growth factor receptor 1.
