Table 2.
Distribution and functional content of HisR regulons in Firmicutes
| Order | Genera (examples) | Target genes | Count |
|---|---|---|---|
| Bacillales (126 genomes) | Bacillus; Brevibacillus; Geobacillus; Paenibacillus; etc | his operon | 40 |
| Bacillus; Brevibacillus; Paenibacillus; Solibacillus; Staphylococcus etc | his operon; yuiF | 52 | |
| Desmospora; Kurthia; Lysinibacillus; Salinicoccus; etc | his operon; hisR | 26 | |
| Lactobacillales (4 genomes) | Enterococcus, Carnobacterium | tdcP-tdcA-tyrT | 4 |
| Eubacteriales (169 genomes) | Clostridium; Eubacterium; Ruminococcus; Subdoligranulum; etc | his operon | 22 |
| Alkaliphilus; Clostridium | his operon; yuiF | 2 | |
| Christensenella; Anaerostipes; Blautia; Butyrivibrio; Coprococcus; etc | his operon; hisR | 114 | |
| Lachnobacterium; Lachnoclostridium; Bryantella; Roseburia; etc | his operon; hisXYZ* | 86 | |
| Clostridium | yuiF | 3 | |
| Clostridium; Eubacterium; Caloramator | hisXYZ* | 6 | |
| Eubacterium; Blautia; Oribacterium; Peptococcus; Flavonifractor; etc | hisR; hisXYZ* | 8 | |
| Halanaerobiales (7 genomes) | Halanaerobium; Halothermothrix | his operon | 2 |
| Halanaerobium; Halobacteroides | his operon; yuiF | 3 | |
| Acetohalobium | his operon; hisR | 1 | |
| Orenia | his operon; hisXYZ* | 1 | |
| Natranaerobiales | Natranaerobius (1 genome) | his operon; hisR | 1 |
| Thermoanaero-bacterales (36 genomes) | Caldicellulosiruptor; Desulfovirgula; Moorella; Caldanaerovirga; etc | his operon | 29 |
| Carboxydothermus; Thermoanaerobacter | his operon; hisR | 7 | |
| Acidaminococcales (4 genomes) | Acidaminococcus | his operon; hisR | 2 |
| Phascolarctobacterium; Succinispira | his operon; hisXYZ* | 2 | |
| Selenomonadales (16 genomes) | Megamonas; Mitsuokella;Selenomonas; Anaeromusa; Thermosinus | his operon; hisXYZ*; hisR | 14 |
| Pelosinus; Selenomonas | hisXYZ*; hisR | 2 | |
| Veillonellales (11 genomes) | Dialister; Megasphaera; Veillonella | his operon; hisXYZ*; hisR | 8 |
| Anaeroglobus; Megasphaera; Veillonella | his operon; hisXYZ* | 7 | |
| Tissierellales (13 genomes) | Anaerococcus; Finegoldia; Parvimonas | hisR | 7 |
| Gottschalkia | his operon | 1 | |
| Peptoniphilus | yuiF | 5 | |
| TOTAL number of operons controlled by HisR (387 genomes): | 635 | ||
The HisZ component of histidine ABC transporter is marked with asterisk to distinguish it from eponymous enzyme