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. 2022 Aug 26;41:261. doi: 10.1186/s13046-022-02462-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — circCCDC134 facilitates CC proliferation and metastasis. A The qPCR results showed that Si-circCCDC134-1 and Si-circCCDC134-2 could significantly inhibit circCCDC134 expression in CC cells (ME180 and SiHA cells). B and C Colony formation and D, E and F: Transwell assays revealed the role of circCCDC134 in promoting the proliferation and metastasis of CC cells. Xenografts formed by ME180 cells bearing sh-circCCDC134 exhibited a significantly slower growth rate (G and H) and lower tumour weight (I) than scrambled controls. In the lung metastasis models (5 nude mice in the sh-NC group and 5 nude mice in the sh-circCCDC134 group), J and H: the volumes and the number of metastatic nodes were significantly decreased in the sh-circCCDC134 group