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. 2022 Aug 26;41:261. doi: 10.1186/s13046-022-02462-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — circCCDC134 contributes to abnormal gene expression in CC. A and B Heatmap of mRNA-seq data of CC and metastatic tissues. C and D Heatmap and scatterplot results of si-circCCDC134 mRNA-seq data. E and F KEGG and GSEA based on si-circCCDC134 mRNA-seq data. G GSEA of the TNF signalling pathway. H and I Identification of potential TNF and EMT mRNAs regulated by circCCDC134. J Heatmap of TNF and EMT mRNAs regulated by circCCDC134. K and L The expression of EFNA1 was decreased in ME180 and SiHA cells and increased in HCC94 cells that were induced by circCCDC134. KLF2, PER1 and COL5A3 expression was increased in ME180 and SiHA cells and decreased in HCC94 cells induced by circCCDC134