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. 2022 Aug 8;13(8):1279. doi: 10.3390/mi13081279

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The in vitro magnetic responsiveness of iron oxide magnetic nanoparticles (MNPs) measuring 10 nm (Fe₃O₄-10), 60 nm (Fe₃O₄-60), 120 nm (Fe₃O₄-120), 200 nm (Fe₃O₄-200), and 310 nm (Fe₃O₄-310). (a) The images of fluorescent DOX-loaded MNPs before and after magnetic targeting with an external magnetic field in static mode. (b) A schematic diagram showing magnetic targeting in dynamic mode with a microfluidic system simulating nanoparticle retention in blood circulation, under the guidance of an external magnetic field. (c) The time-lapsed photographs of the magnetic retention of different nanoparticles in the flow system shown in (b) at the 32.85 cm/s flow rate found in the artery. Reprinted/adapted with permission from Ref. [97]. 2017, American Chemical Society.