Table 1.

Commercially available honey-based wound healing products.

Product	Manufacturer	Description	Indications	Mechanism of Action	Ref.	Clinical Evidence
Activon® Manuka Honey Tube	Advancis Medical	100% medical-grade manuka honey	Any wound type but especially sloughy, necrotic, and malodorous wounds, including: pressure ulcers, leg ulcers, diabetic ulcers, surgical wounds, burns, graft sites, infected wounds, cavity wounds and sinuses	Debrides necrotic tissue; can be used in dressings or directly into cavities.	[154]	Inhibition of in vitro formation of clinically important Gram-positive bacteria biofilms [155]. Blistering and cellulitis on a type 2 diabetic patient; paediatric burn; foot ulceration; grade 5 sacral wound [154]
Activon® Tulle	Advancis Medical	Knitted viscose mesh dressing impregnated with 100% manuka honey	Granulating or shallow wounds, good when debriding or de-sloughing small areas of necrotic or sloughy tissue	Creates a moist healing environment, eliminates wound odour, and provides antibacterial action	[154]	Overgranulated grade 3 and 4 pressure ulcers; extensive leg cellulitis; venous ulcer; chronic wound infections; necrotic foot [154]
Algivon® Plus	Advancis Medical	Reinforced alginate dressing impregnated with 100% manuka honey	Pressure, leg and diabetic ulcers, surgical wounds, burns, graft sites and infected wounds. Ideal for wetter wounds	Absorbs exudate. Debrides, removes slough, and reduces bacterial load	[154]	Chronic wounds [156]; burn wound management [157]
Algivon® Plus Ribbon	Advancis Medical	Reinforced alginate ribbon impregnated with 100% manuka honey	Cavities, sinuses, pressure ulcers, leg ulcers, diabetic ulcers, surgical wounds, burns, graft sites, and infected wounds	Absorb exudates. Debrides, removes slough, and reduces bacterial load	[154]	Autoamputation of fingertip necrosis [158]
Aurum® ostomy bags	Welland Medical Ltd.	Medical-grade manuka honey added to the hydrocolloid	Stoma care	Kills bacteria, suppresses inflammation, and stimulates the growth of cells to promote healthy skin around the stoma	[159]	Pyoderma gangrenosum around ileostomy [160]
L-Mesitran® Border	Aspen Medical Europe Ltd.	Combined hydrogel and honey (30%) pad on a strong fixation layer	Chronic wounds, such as: pressure ulcers; superficial and partial-thickness burns; venous, arterial, and diabetic ulcers.	Exudate absorption. Donates moisture to rehydrate dry tissue. Antibacterial properties. Helps to maintain a moist wound environment	[161]	Paediatric minor burns and scalds [162]
L-Mesitran® Hydro	Aspen Medical Europe Ltd.	Sterile, semi-permeable hydrogel dressing containing 30% honey with vitamin C and E, as well as an acrylic polymer gel and water, with a polyurethane film backing	Low to moderate exuding wounds, including: chronic wounds (pressure ulcers, venous and diabetic ulcers), superficial and acute wounds (cuts, abrasions and donor sites), superficial and partial-thickness burns (first- and second-degree), fungating wounds, acute wounds, e.g., donor sites, surgical wounds, cuts and abrasions	Donates moisture to rehydrate dry tissue. Antibacterial properties. Helps to maintain a moist wound environment	[161]	Paediatric minor burns and scalds [162]. Fungating wounds [163]
L-Mesitran® Ointment	Aspen Medical Europe Ltd.	Ointment with 48% medical-grade honey, medical-grade hypoallergenic lanolin, oils, and vitamins	Superficial, acute, and chronic wounds. Superficial and partial-thickness burns. Fungating wounds (to help deodorise and debride). Colonised acute wounds and (postoperative) surgical wounds	Aids debridement and reduce bacterial colonisation	[161]	Skin tears; irritation and inflammation [163]
ManukaDress IG	Medicareplus International	Wound dressing made with 100% Leptospermum scoparium sterile honey from New Zealand. Non-adherent impregnated gauze	Leg and pressure ulcers, first- and second-degree burns, diabetic foot ulcers, surgical and trauma wounds	Osmotic activity that promotes autolytic debridement and helps maintain a moist wound environment	[164]	Burn management [165]. Difficult-to-debride wounds [166]. Necrotic pressure ulcer; recurrent venous leg ulceration [167]
Medihoney® Antibacterial Honey	Derma Sciences—Comvita	100% sterilised medical-grade manuka honey	All types of wounds with low to moderate exudate, including: deep, sinus, necrotic, infected, surgic and malodorous wounds®	Creates an antibacterial environment (MGO). Autolytic debridement on sloughy and necrotic tissue. Removes malodour. Provides a moist environment.	[168]	Wound healing [169]; prevention of catheter-associated infections in haemodialysis patients [170]
Medihoney® Apinate Dressing	Derma Sciences—Comvita	Calcium alginate dressing impregnated with 100% medical-grade manuka honey	Moderately to heavily exuding wounds such as: diabetic foot ulcers, leg ulcers, pressure ulcers (partial- and full-thickness), first- and second-degree partial-thickness burns, donor sites and traumatic or surgical wounds.	Promotes a moisture-balanced environment. Osmotic potential draws fluid through the wound to the surface. Low pH of 3.5–4.5.	[171]	Venous leg ulcers [172]
Medihoney® Barrier Cream	Derma Sciences—Comvita	Barrier cream containing 30% medical-grade manuka honey	Use to protect skin from breakdown (e.g., skin damaged by irradiation treatment or in wet areas due to incontinence). Additionally, to prevent damage caused by shear and friction	Maintains skin moisture and pH.	[173]	Treatment for intertrigo in large skin folds [174]
Medihoney® Antibacterial Wound Gel™	Derma Sciences—Comvita	Antibacterial wound gel: 80% medical-grade manuka honey with natural waxes and oils	Surface wounds with low to moderate exudate and partial- and full-thickness wounds, including burns, cuts, grazes, and eczema wounds	Creates a moist, low-pH environment. Cleans the wound through osmotic effect. Reduces the risk of infection (MGO)	[175]	Reduction in incidence of wound infection after microvascular free tissue reconstruction [176]
SurgihoneyRO™	Matoke Holdings Ltd.	Antimicrobial wound gel utilising bioengineered honey to deliver Reactive Oxygen® (RO™)	Infected, chronic (diabetic foot, pressure, and leg ulcers) and acute (surgical, traumatic and abrasions wounds, cuts, burns, donor and recipient sites) wounds	Controlled release of hydrogen peroxide release for antimicrobial activity. Promotes debridement and new tissue growth	[177]	Prevention of caesarean wound infection; prevention/eradication of bacterial colonies in dressing oncology long vascular lines; ulcers, surgical wounds and trauma wounds [178,179,180]. In vitro activity against biofilm-producing clinical bacterial isolates [181]