Table 4.

Multivariate analysis of OS in patients with oral cavity squamous cell carcinoma

Variable		Univariate analysis		Multivariate analysis
	Survival	HR (95% CI)	P	HR (95% CI)	P
Sex
Women	76.1%	Reference		Reference
Men	68.1%	1.541 (0.709-3.351)	0.275	0.997 (0.443-2.243)	0.995
Age (years)
< 65	70.2%	Reference		Reference
≥ 65	65.7%	1.261 (0.801-1.986)	0.316	1.037 (0.619-1.737)	0.890
AJCC stage
I	91.6%	Reference		Reference
II	81.5%	1.653 (0.555-4.919)	0.367	2.159 (0.712-6.544)	0.174
III	85.0%	1.331 (0.446-3.972)	0.608	1.354 (0.449-4.085)	0.590
IV	52.7%	5.157 (2.228-11.935)	<0.001	3.811 (1.476-9.839)	0.006
PNI
Absent	74.3%	Reference		Reference
Present	52.9%	2.178 (1.395-3.398)	0.001	1.443 (0.854-2.439)	0.171
Cell differentiation
W-D/M-D	72.8%	Reference		Reference
P-D	39.7%	3.396 (2.000-5.768)	<0.001	3.157 (1.686-5.912)	<0.001
Surgical margin
≥ 5 mm	72.9%	Reference		Reference
< 5mm	58.6%	1.703 (1.091-2.658)	0.019	1.319 (0.806-2.159)	0.271
Tumor sites
Tongue	72.0%	Reference
Buccal mucosa	65.7%	1.295 (0.774-2.168)	0.325
Other	68.8%	1.188 (0.700-2.018)	0.523
Personal habits
No exposure	75.3%	Reference
One exposure	53.4%	2.245 (0.814-6.193)	0.118
Two or all exposure	69.4%	1.439 (0.661-3.134)	0.359
Adjuvant chemotherapy
No	79.4%	Reference		Reference
Yes	52.1%	2.907 (1.881-4.492)	<0.001	1.388 (0.724-2.162)	0.570
CCI
0	74.9%	Reference		Reference
1	66.4%	1.457 (0.877-2.423)	0.146	1.228 (0.705-2.136)	0.468
≥ 2	57.9%	1.965 (1.157-3.335)	0.012	1.431 (1.073-3.087)	0.033
CALLY index
≥ 0.65	80.6%	Reference		Reference
< 0.65	42.2%	4.544 (2.934-7.037)	<0.001	3.816 (2.393-6.086)	<0.001