Table 5.

Multivariate analysis of DFS in patients with oral cavity squamous cell carcinoma

Variable		Univariate analysis		Multivariate analysis
	Survival	HR (95% CI)	P	HR (95% CI)	P
Sex
Women	69.7%	Reference		Reference
Men	49.8%	1.613 (0.864-3.011)	0.133	1.180 (0.625-2.225)	0.610
Age (years)
< 65	51.5%	Reference		Reference
≥ 65	53.3%	0.914 (0.622-1.343)	0.647	0.884 (0.594-1.318)	0.546
AJCC stage
I	70.5%	Reference		Reference
II	66.7%	0.937 (0.447-1.964)	0.864	1.072 (0.508-2.261)	0.855
III	65.9%	1.002 (0.499-2.013)	0.994	1.114 (0.550-2.256)	0.764
IV	37.6%	2.445 (1.452-4.118)	0.001	2.443 (1.333-4.479)	0.004
PNI
Absent	55.0%	Reference
Present	43.1%	1.355 (0.922-1.991)	0.122
Cell differentiation
W-D/M-D	55.1%	Reference		Reference
P-D	30.5%	2.383 (1.487-3.819)	<0.001	2.560 (1.535-4.269)	<0.001
Surgical margin
≥ 5 mm	54.8%	Reference
< 5mm	44.9%	1.369 (0.947-1.978)	0.095
Tumor sites
Tongue	57.8%	Reference
Buccal mucosa	48.1%	1.203 (0.789-1.834)	0.390
Other	48.2%	1.349 (0.890-2.045)	0.158
Personal habits
No exposure	70.3%	Reference
One exposure	41.5%	2.067 (0.859-4.972)	0.105
Two or all exposure	50.6%	1.744 (0.911-3.338)	0.093
Adjuvant chemotherapy
No	58.9%	Reference		Reference
Yes	41.1%	1.761 (1.247-2.486)	0.001	1.369 (0.687-2.415)	0.260
CCI
0	53.2%	Reference
1	51.6%	1.083 (0.724-1.621)	0.698
≥2	50.2%	1.127 (0.719-1.765)	0.603
CALLY index
≥ 0.65	59.3%	Reference		Reference
< 0.65	35.0%	2.260 (1.594-3.203)	<0.001	2.103 (1.451-3.049)	<0 0.001