Table 3.
Overview of genetically modified live PRV strains for vaccination in pigs.
| Gene-Deleted Vaccines | Vaccine Strains | Progenitor Strains | Deleted Gene | Technology Used | Authorization | References |
|---|---|---|---|---|---|---|
| Single gene-deleted vaccine | Omnivac | BUK | TK gene | Natural losses | Licensed | [27] |
| 2.4N3A | NIA-3 (field strain) | gE gene | HR | Licensed | [166] | |
| PRV(LA-AB) | AH02LA (field strain) | gE gene | BCA | Not available | [167] | |
| HN1201ΔgE (inactivated) |
HN1201 (field strain) | gE gene | HR | Licensed | [154] | |
| rPRVTJ-delgE | TJ (field strain) | gE gene | HR | Not available | [11] | |
| Double gene-deleted vaccine | Omnimark | Omnivac (BUK) | TK and gIII genes | Natural losses | Licensed | [145] |
| Begonia | 2.4N3A (NIA-3) | TK and gE genes | Natural losses | Licensed | [168] | |
| NIA3-783 | 2.4N3A (NIA-3) | TK and gE genes | HR | Licensed | [146] | |
| Tolvi | field strain | TK and gpX genes | HR | Licensed | [169] | |
| D1200/D560 | NIA-3 | gD and gI genes | HR | Not available | [148] | |
| AD-YS400 | Yangsan (field strain) | TK and gE genes | HR | Not available | [170] | |
| JS-2012-ΔgE/gI | JS-2012 (field strain) | gE and gI genes | HR | Not available | [171] | |
| gE-TK-PRV | TNL (field strain) | TK and gE genes | HR | Not available | [172] | |
| vZJ01ΔgE/gI (inactivated) | ZJ01 (field strain) | gE and gI genes | BCA | Not available | [157] | |
| PRV (PRVΔTK&gE-AH02) | AH02LA (field strain) | TK and gE genes | HR | Not available | [173] | |
| Triple gene-deleted vaccine | 6C2 | Field strain | TK, gE and gI genes | HR | Not available | [174] |
| SA215 | Fa (classical strain) | gE, gI and TK genes | HR | Licensed | [175] | |
| rSMXΔgI/gEΔTK | Field strain | TK, gE and gI genes | HR | Not available | [176] | |
| rPRVTJ-delgE/gI/TK- | rPRVTJ-delgE (TJ strain) | TK, gE and gI genes | HR | Not available | [29] | |
| vPRV HN1201 | HN1201 (field strain) | TK, gE and gI genes | HR | Not available | [158] | |
| gE-/gI-/TK- PRV | HeN1 (field strain) | TK, gE and gI genes | CRISPR/Cas9 | Not available | [177] | |
| rPRV NY-gE−/gI−/TK− | NY (field strain) | TK, gE and gI genes | HR and CRISPR/Cas9 | Not available | [155] | |
| 201715 (field strain) | gE, gC and TK genes | CRISPR/Cas9 | Not available | [178] | ||
| rPRV/XJ5-gE−/gI−/TK− | XJ5 (field strain) | gE, gI and TK genes | HR | Not available | [159] | |
| rGXΔTK/gE/gI | GX (field strain) | TK, gE and gI genes | Not available | [165] | ||
| Four gene-deleted vaccine | PrV (376) | PrV (376) | gD, gG, gI and gE genes | Not available | [147] | |
| —— | C (field strain) | gI, gE, Us9 and Us2 genes | Natura losses | Licensed | [179] | |
| PRV GDFS-delgI/gE/US9/US2 | GDFS (field strain) | gI, gE, Us9 and Us2 genes | CRISPR/Cas9 | Not available | [161] | |
| rZJ01-ΔgI/gE/TK/UL13 | ZJ01 | gI, gE, TK and UL13 genes | CRISPR/Cas9 | Not available | [29] | |
| Five gene-deleted vaccine | PRV rHN1201TK−/gE−/gI−/11k−/28k− | HN1201 (field strain)) | TK, gI, gE, 11k and 28k genes | BCA | Not available | [164] |
Note: HR is the homologous DNA recombination; BCA is the bacterial artificial chromosome; CRISPR/Cas9 is the clustered regularly interspaced short palindromic repeats/Cas9.