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. 2022 Aug 4;10(8):1251. doi: 10.3390/vaccines10081251

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CV2CoV induced higher virus neutralising antibody (nAb) titres against ancestral SARS-CoV-2 than CVnCoV. Groups of female and male Wistar rats (n = 6/group) were vaccinated IM with five different doses ranging from 0.5 µg to 40 µg of CVnCoV or CV2CoV on D0 and D21. Rats (n = 4) vaccinated with 0.9% NaCl (buffer) served as negative controls. SARS-CoV-2 virus neutralising antibody (nAb) titres in serum samples taken on (A) D14, (B) D21 and (C) D42 were analysed. The highest dilution was 1:5120. Each dot represents an individual animal, and vertical lines show the range. Mann-Whitney test was used to compare groups. * = p < 0.05, ** = p < 0.01.