Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 4;10(8):1251. doi: 10.3390/vaccines10081251

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Two doses of CV2CoV on D0 and D21 induced higher virus neutralising antibody (nAb) titres on D42 against (A) ancestral SARS-CoV-2 and the variants (B) B1.1.298, (C) B.1.1.7 and (D) B1.351 compared with two doses of CVnCoV. Groups of female and male Wistar rats (n = 6/group) were vaccinated IM with five different doses ranging from 0.5 µg to 40 µg of CVnCoV or CV2CoV on D0 and D21. Rats (n = 4) vaccinated with 0.9% NaCl (Buffer) served as negative controls. SARS-CoV-2 virus neutralising antibody (nAb) titres in serum samples taken on D42 were analysed. The highest dilution was 1:5120. Each dot represents an individual animal. The median nAb titres are shown above each bar and the vertical lines show the range. Mann-Whitney test was used to compare groups. * = p < 0.05, ** = p < 0.01.