Table 1.
Clinical data of dogs diagnosed with gliomas treated with surgery and chemotherapy.
| Breed | Sex | Neutered (Y/N) | Age (yrs) | Weight (kg) | Primary Complaint | Neurological Exam | Tumour Localization | Surgery (N) | Histopathology | Chemotherapy | Tumour Relapse | Survival Time (Days) | Cause Death |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| French Bulldog | M | Y | 8 | 13.0 | Seizures | Left circling and right proprioceptive deficits | Left temporal lobe | 1 | Glioblastoma grade IV | Temozolomide (181.8 mg/m2 for 5 days every 3 weeks) | Suspected | 456 | Euthanasia due to clinical signs of relapse |
| French Bulldog | F | Y | 8 | 9.8 | Seizures | Obtunded mental status, right circling, ambulatory tetraparesis, decreased left menace response and facial sensation | Right frontal lobe | 1 | Anaplastic oligodendroglioma grade III | Temozolomide (109.0 mg/m2 for 5 days every 3 weeks) | Suspected | 190 | Euthanasia due to clinical signs of relapse |
| French Bulldog | M | N | 9 | 14.6 | Seizures | Normal | Right temporal lobe | 1 | Oligodendroglioma grade II | Temozolomide (100.0 mg/m2 for 5 days every 3 weeks) | Suspected | 300 | Euthanasia due to clinical signs of relapse |
| French Bulldog | F | Y | 9 | 9.2 | Seizures | Decreased menace response OS | Right temporal lobe | 1 | Glioblastoma grade IV | Temozolomide (93.0 mg/m2 for 5 days every 3 weeks) | Suspected | 150 | Euthanasia due to clinical signs of relapse |
| Boxer | F | Y | 10 | 37.2 | Seizures | Obtunded mental status, right circling, ambulatory tetraparesis, decreased left menace response and facial sensation | Left frontal lobe | 1 | Anaplastic oligodendroglioma grade III | 1st Temozolomide (110. mg/m2 for 5 days every 3 weeks) 2nd Melphalan (0.15 mg/kg for 5 days every 3 weeks) | Suspected | 493 | Euthanasia due to clinical signs of relapse |
| French Bulldog | F | Y | 10 | 15.3 | Seizures | Mild right proprioceptive deficits | Left frontal lobe | 1 | Oligodendroglioma grade II | Temozolomide (100.0 mg/m2 for 5 days every 3 weeks) | Suspected | 51 | Euthanasia due to clinical signs of relapse |
| French Bulldog | M | N | 7 | 14.0 | Seizures | Normal | Left frontal lobe | 1 | Anaplastic oligodendroglioma grade III | Temozolomide (76.9 mg/m2 for 5 days every 3 weeks) | Suspected | 160 | Euthanasia due to clinical signs of relapse |
| French Bulldog | M | N | 7 | 13.5 | Seizures | Normal | Left frontal lobe | 1 | Anaplastic oligodendroglioma grade III | Temozolomide (76.9 mg/m2 for 5 days every 3 weeks) | Suspected | 180 | Euthanasia due to clinical signs of relapse |
| English Bulldog | F | Y | 4 | 25.5 | Obtundedmental status | Right circling, left proprioceptive deficits, decreased menace response OS | Left cerebellum | 1 | Anaplastic oligodendroglioma grade III | 1st Temozolomide (160.9 mg/m2 for 5 days every 3 weeks) | CT confirmed | 120 | Euthanasia due to tumour regrowth |
| French Bulldog | M | N | 5 | 13.3 | Seizures | Mild right proprioceptive deficits and decreased menace response OD | Left frontal lobe | 1 | Oligodendroglioma grade II | 1st Temozolomide 181.8 mg/m2 for 5 days every 3 weeks) 2nd Lomustine (70 mg/m2 every 3 weeks) | CT confirmed | 240 | Euthanasia due to tumour regrowth |
| Boxer | F | N | 9 | 28.5 | Seizures | Lumbosacral pain | Right occipital lobe | 2 | 1st Anaplastic oligodendroglioma grade III 2nd Gliosarcoma grade IV | 1st Temozolomide (76.9 mg/m2 for 5 días every 3 weeks) 2nd Toceranib phosphate (2.8 mg/kg 3 times weekly) | CT & biopsy confirmed | 241 | Euthanasia due to tumour regrowth |
| French Bulldog | F | Y | 8 | 8.9 | Seizures | Decrease pupillary reflex OD | Right olfactory lobe | 2 | 1st Anaplastic oligodendroglioma grade III 2nd Anaplastic oligodendroglioma grade III | Temozolomide (93.0 mg/m2 for 5 days every 3 weeks) | CT & biopsy confirmed | 428 | Euthanasia due to aspiration pneumonia two days after the second surgery. CT ruled out IC haemorrhage |
| Boxer mix | F | Y | 8 | 21.3 | Seizures | Mild left proprioceptive deficits | Left frontal lobe | 2 | 1st Oligodendroglioma grade II 2nd Oligodendroglioma grade II | 1st Temozolomide (76.4 mg/m2 for 5 days every 3 weeks) 2nd Lomustine (70 mg/m2 every 3 weeks) | CT & biopsy confirmed | 468 | Euthanasia due to tumour regrowth |
| French Bulldog | F | Y | 8 | 14.5 | Seizures | Left pelvic limb proprioceptive deficits and decreased menace response OS | Right parietal lobe | 3 | 1st Anaplastic oligodendroglioma grade III 2nd Anaplastic oligodendroglioma grade III 3rd Anaplastic oligodendroglioma grade III | 1st Temozolomide (81.6 mg/m2 for 5 days every 3 weeks) 2nd Toceranib phosphate (2.5 mg/kg 3 times weekly) 3rd Lomustine (70 mg/m2 every 3 weeks) | CT & biopsy confirmed | 780 | Euthanasia due to tumour regrowth |
kg = kilograms; n = number; F = female; M = male; Y = yes; N = no; yrs = years; OS = left eye; OD = right eye, CT = computed tomography, IC = intracranial haemorrhage.