Table 1.
Characteristics of prepared hard capsule samples.
| Sample ** | Coating | The Practical Content of Caffeine per Capsule ± SD (mg) | Mean Weight of Uncoated Capsules ± SD (mg) | ||
|---|---|---|---|---|---|
| Polymer | % | Solvent | |||
| DR_Eu10 | Eudragit® S | 10 | Ethanol (96%) | 101.50 ± 4.63 | 500.71 ± 10.96 |
| DR_Eu15 | 15 | 98.40 ± 5.54 | 497.10 ± 9.38 | ||
| DR_Eu20 | 20 | 103.40 ± 6.51 | 510.93 ± 3.16 | ||
| DR_Ac10 | Acryl-EZE® | 10 | Purified Water | 99.20 ± 4.96 | 498.20 ± 10.05 |
| DR_Ac15 | 15 | 102.10 ± 5.47 | 499.37 ± 10.60 | ||
| DR_Ac20 | 20 | 95.60 ± 3.56 | 518.78 ± 8.58 | ||
| DR_Ce10 | Cellacefate | 10 | Acetone | 97.80 ± 5.96 | 456.37 ± 4.49 |
| DR_Ce15 | 15 | 103.40 ± 2.91 | 528.25 ± 7.97 | ||
| DR_Ce20 | 20 | 99.30 ± 4.47 | 432.36 ± 6.45 | ||
| Ge_Eu10 | Eudragit® S | 10 | Ethanol (96%) | 102.80 ± 5.19 | 511.18 ± 11.03 |
| Ge_Eu15 | 15 | 105.90 ± 5.82 | 509.95 ± 7.58 | ||
| Ge_Eu20 | 20 | 101.10 ± 4.59 | 514.89 ± 7.55 | ||
| Ge_Ac10 | Acryl-EZE® | 10 | Purified Water | 100.60 ± 5.43 | 501.83 ± 10.57 |
| Ge_Ac15 | 15 | 103.30 ± 4.96 | 504.73 ± 8.52 | ||
| Ge_Ac20 | 20 | 98.10 ± 4.87 | 520.10 ± 8.74 | ||
| Ge_Ce10 | Cellacefate | 10 | Acetone | 103.90 ± 5.86 | 423.63 ± 9.05 |
| Ge_Ce15 | 15 | 103.70 ± 5.59 | 529.19 ± 8.05 | ||
| Ge_Ce20 | 20 | 105.50 ± 5.28 | 439.06 ± 8.29 | ||
Each sample consists of 20 capsules, with theoretical content of 100 mg of caffeine per capsule. ** Abbreviation of each sample was established by the type of capsule [Gelatin capsules (Ge); DRcapsTM (DR)]; the enteric polymer employed [Eudragit® S (Eu); Cellacefate (Ce); Acryl-EZE® (Ac)]; and the percentage of prepared dispersion.