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. 2022 Jul 29;14(8):1577. doi: 10.3390/pharmaceutics14081577

Table 4.

Comparison of dissolution profiles through similarity factor f2 and dissolution efficiency as ΔDE (%) expressed in 3 different levels, where two parameters are constant, and one is changeable: (A) Polymer concentration; (B) Polymer type; (C) Capsule type.

(A) Polymer Concentration
Compared samples f2/ΔDE (%) Compared samples f2/ΔDE (%)
DR_Ce10 */DR_Ce15 15.28/−75.78 Ge_Ce10 */Ge_Ce15 35.32/−29.61
DR_Ce10 */DR_Ce20 15.89/−73.47 Ge_Ce10 */Ge_Ce20 26.51/−52.17
DR_Ce15 */DR_Ce20 79.44/9.53 ** Ge_Ce15 */Ge_Ce20 46.44/−32.05
DR_Eu10 */DR_Eu15 66.12/11.35 ** Ge_Eu10 */Ge_Eu15 53.72/−0.64 **
DR_Eu10 */DR_Eu20 37.87/48.4 Ge_Eu10 */Ge_Eu20 18.69/−45.69
DR_Eu15 */DR_Eu20 42.12/33.27 Ge_Eu15 */Ge_Eu20 20.6/−45.34
DR_Ac10 */DR_Ac15 46.25/−11.64 Ge_Ac10 */Ge_Ac15 28.04/−10.84
DR_Ac10 */DR_Ac20 16.3/−47.28 Ge_Ac10 */Ge_Ac20 19.06/−26.76
DR_Ac15 */DR_Ac20 22.49/−40.33 Ge_Ac15 */Ge_Ac20 36.31/−17.86
(B) Polymer Type
Compared samples f2/ΔDE (%) Compared samples f2/ΔDE (%)
DR_Eu10 */DR_Ce10 25.05/91.94 Ge_Eu10 */Ge_Ce10 28.78/−29.79
DR_Ce10 */DR_Ac10 23.95/25.84 Ge_Ce10 */Ge_Ac10 14.23/74.88
DR_Eu10 */DR_Ac10 13.34/141.54 Ge_Eu10 */Ge_Ac10 28.9/22.79
DR_Eu15 */DR_Ce15 32.43/−58.25 Ge_Eu15 */Ge_Ce15 19.0/−50.26
DR_Ce15 */DR_Ac15 12.3/359.04 Ge_Ce15 */Ge_Ac15 14.17/121.53
DR_Eu15 */DR_Ac15 20.7/91.66 Ge_Eu15 */Ge_Ac15 45.77/10.19
DR_Eu20 */DR_Ce20 22.62/−65.69 Ge_Eu20 */Ge_Ce20 40.66/−38.17
DR_Ce20 */DR_Ac20 28.63/150.07 Ge_Ce20 */Ge_Ac20 17.39/167.8
DR_Eu20 */DR_Ac20 52.19/−14.19 ** Ge_Eu20 */Ge_Ac20 24.91/65.6
(C) Capsule Type
Compared samples f2/
ΔDE (%)
Compared samples f2/
ΔDE (%)
Compared samples f2/
ΔDE (%)
DR_Ce10 */Ge_Ce10 15.28/
160.21
DR_Eu10 */Ge_Eu10 6.14/
753.98
DR_Ac10 */Ge_Ac10 12.97/
49.85
DR_Ce15 */Ge_Ce15 8.54/
1546.18
DR_Eu15 */Ge_Eu15 6.22/
557.71
DR_Ac15 */Ge_Ac15 13.63/
83.04
DR_Ce20 */Ge_Ce20 10.42/
1102.78
DR_Eu20 */Ge_Eu20 11.52/
392.4
DR_Ac20 */Ge_Ac20 7.97/
464.25

* Reference sample, ** Similar dissolution profiles.