Table 1.
Breast cancer biopredictors. (The unlabeled biomarkers were all blood from breast cancer patients).
| Biomarker | Clinical Significance |
|---|---|
| Positive correlation: miR-1246, miR-21 [108]; miR-202 [109]; has-miR-21–5p [110]; miR-106a-3p, miR-106a-5p, miR-20b-5p, miR-92a-2-5p (in plasma); miR-106a-5p, miR-19b-3p, miR-20b-5p, miR-92a-3p (in serum) [111]; let-7b-5p, miR-122-5p, miR-146b-5p, miR-210-3p, miR-215-5p [112]; GPC-1, ADAM10, GLUT-1 (CM of BCCs) [113]; RALGAPA2, PKG1, TJP2 [114]; miR-424, miR-423, miR-660, let7-I (Urine of BC patients) [115]. Negative correlation: miR-21 [116] |
The correlation with breast tumorigenesis can be used for tumor screening. |
| miR-1976 [117]; CD82 [118]; miR-363-5p [119]. | Negative correlation with breast tumorigenesis. |
| miR-1910-3p [120]; circHIF1A [121]; circ_0001142 (CM of BCCs) [122] (It also promotes polarization of macrophages); Hsa-miR-576-3p(brain metastases) [123]; miR-200c, miR-141 [124]; CD105 [125]; miR-370-3p [126]; miR-7641 [127]. |
Positive correlation with breast tumor metastasis. |
| Negative correlation: miR421, miR128-1, miR128-2 [128]; lncRNA BCRT1 (CM of BCCs) [129]; lncRNA AFAP1-AS1 [84]; lncRNA SUMO1P3 [130]; NGF [131]; circPSMA1 (CM of TNBC) [132]; UCH-L1 (before chemotherapy) [133]; miR-21, miR-200c (Tears from a patient with metastatic BC) [134]; lncRNA AC073352.1 (CM of BC) [135]; lncRNA H19 [136]; XIST [137]; has_circ_0000615 [138]; miR-223-3p [139]; miR-1910-3p [120]. Positive correlation: miR-148a [140]; miR-188-5p [141] |
Prognostic correlation of breast cancer. |
| Del-1 [142] | The increased expression level after breast cancer operation suggests early recurrence. |
| miR-770 (CM of TNBC) [143] | High expression inhibits migration and invasion, and inhibits doxorubicin resistance in TNBC cell lines. |
| LncRNA HOTAIR [144] | Positive correlation with HER2 expression in tumor tissue. |
| GSTP1(CM of drug-resistant BCCs) [145] | High expression indicates transfer resistance. |
| TRPC5 [146] | The increased expression after chemotherapy suggested an increase in acquired chemical resistance. |
| LDH-C4 [147] | It was negatively correlated with drug therapy and positively correlated with relapse of BC. |