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. 2022 Aug 3;11(8):875. doi: 10.3390/pathogens11080875

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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M-T5—an activator of the Akt serine/threonine kinase. The MYXV M-T5 protein binds the cellular Akt serine/threonine kinase when phosphorylated on threonine (T) 308. This promotes the further phosphorylation of Akt on serine (S) 473 to fully activate the kinase. The activation of Akt is proposed to lead to the phosphorylation of the cyclin-dependent kinase inhibitor p27^kip1 on T187. The phosphorylation of p27^kip1 on this site is then recognized by the cellular SCF^skp2 E3 Ub ligase, resulting in the Ub-mediated degradation of p27^kip1. This overcomes the cell cycle block and allows MYXV infection to proceed.