Table 1.
Summary of ANKR/F-box genes discussed in this review.
| E3 Ligase(s) | Poxvirus | Cellular Target Recognized | Target Degradation (Yes/No) |
Role during Infection |
|---|---|---|---|---|
| C9 | VACV | IFITs | Yes | Block IFIT anti-viral activity |
| vIRD | CPXV | RIPK3 | Yes | Prevent necroptosis-associated inflammation |
| NF-κB1 p105 | No | Prevent expression of NF-κB-associated inflammatory genes | ||
| M-T5 | MYXV | Akt | No | Allow for cell cycle progression and productive infection |
| ORFs 008, 123, 126, 128, and 129 | ORFV | FIH | No | Promote expression of HIF-responsive genes to support viral replication? |