Table 2.

Univariable and multivariable analysis of parameters for progression-free survival

Parameters	Univariable analysis			Multivariable analysis
	HR	95% CI	P value	HR	95% CI	P value
Age ≥ 60 years	0.993	0.783—1.260	0.957
Female	0.957	0.752—1.217	0.719
BMI ≥ 24 kg/m2	0.891	0.706—1.124	0.328
ASA score 1–2	1.051	0.724—1.526	0.794
Primary site colon	1.052	0.833—1.330	0.669
Right hemicolon	1.066	0.781—1.453	0.688
R0 resectiona	0.515	0.404—0.658	< 0.001*	0.583	0.453—0.748	< 0.001*
Poorly differentiateda	1.286	0.990—1.671	0.060			0.684
T3-T4a	1.490	0.935—2.374	0.093			0.262
N1-N2a	1.749	1.332—2.295	< 0.001*	1.511	1.145—1.994	0.004*
Synchronous metastasisa	1.451	1.087—1.937	0.012*			0.143
Extrahepatic metastasesa	1.612	1.160—2.239	0.004*	1.416	1.015—1.976	0.041*
Diameter of metastases > 5 cm	1.038	0.722—1.492	0.841
Multiple metastasesa	1.997	1.571—2.539	< 0.001*			0.063
Bilobar distributiona	2.035	1.603—2.583	< 0.001*			0.115
Preoperative CEA > 50 ng/mla	1.569	1.183—2.082	0.002*	1.400	1.053—1.861	0.021*
Major liver resectiona	1.978	1.563—2.503	< 0.001*	1.615	1.266—2.060	< 0.001*
Hepatectomy only	0.869	0.678—1.113	0.267
Radio frequency ablationa	1.818	1.289—2.565	0.001*			0.153
Preoperative chemotherapya	1.481	1.170—1.874	0.001*			0.204
Postoperative chemotherapy	0.870	0.689—1.098	0.241
Comorbidity	0.960	0.760—1.213	0.731
Postoperative complicationa	1.393	1.103—1.757	0.005*			0.161
Postoperative major complication	1.120	0.827—1.517	0.463
Serious operation injury conditiona	1.616	1.279—2.042	< 0.001*			0.062
AMLRI > 3.33a	1.530	1.114—2.101	0.009*	1.462	1.059—2.019	0.021 *
AST > 14 U/L	1.697	1.133—2.542	0.010*
MLR > 0.15	1.397	0.953—2.046	0.086
Blood loss (ml)	1.521	1.157—1.999	0.003*
Operation time (min)	1.572	1.240—1.993	< 0.001*
CRS 3–5	1.608	1.272—2.032	< 0.001*

BMI body mass index, ASA American Society of Anesthesiologists T tumour staging, N lymph node staging, CEA carcinoembryonic antigen, CRS clinical risk score, AMLRI AST·MLR index, AST aspartate aminotransferase, MLR monocyte-to-lymphocyte ratio

^aIncluded in multivariable analysis

*Statistically significant