Table 1.

Brief overview of most important type of nanocarriers used for delivering resveratrol.

Nano System	Effect	Key Properties	Reference
Liposomes	Antioxidant activity	Enhanced solubility and stability of curcumin and resveratrol. Minimum particle size, lower polydispersity index and high encapsulation efficiency	[62]
	Anticancer activity	HepG2 cells exhibited a higher uptake of encapsulated-RES than the free form	[63]
Dendrimers	Enhanced RES solubility and stability in aqueous solution. Dendrimers can be engineered to control pharmacokinetics and target for oral, mucosal, transdermal, or parenteral administration	(PAMAM) dendrimer assembly overcame the problems of low bioavailability and poor water solubility	[64]
Solid lipid nanoparticles	In vitro cytotoxicity against C6 glioma cell lines	The resveratrol-TPGS-SLNs showed 11.12 and 9.37-times higher area under the curve (AUC) and plasma half-life, respectively, than the unprocessed resveratrol. Additionally, the concentration of resveratrol-TPGS-SLNs in the brain was found to be 9.23-times higher compared to free resveratrol	[65]
Polymeric nanoparticles	Fatty liver disorder	The prepared poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing resveratrol increased its stability and solubility, yielding better in vitro results as compared to free drug	[66]