Table 6.
Observed and predicted values of Cmax and AUC0–inf of CorA-povidone and CorA-copovidone after oral administration.
| Parameters | CorA-Povidone | ||||
| Observed |
Predicted
(w/o Dissolution) |
PE (%)
(w/o Dissolution) |
Predicted
(w/ Dissolution) |
PE (%)
(w/ Dissolution) |
|
| Cmax (µg/mL) | 33.24 | 27.43 | 21.18 | 33.80 | −1.68 |
| AUC0–inf (µg·h/mL) | 41.83 | 64.63 | −54.51 | 46.44 | −11.02 |
| Parameters | CorA-Copovidone | ||||
| Observed |
Predicted
(w/o Dissolution) |
PE (%)
(w/o Dissolution) |
Predicted
(w/ Dissolution) |
PE (%)
(w/ Dissolution) |
|
| Cmax (µg/mL) | 5.00 | 20.43 | −308.60 | 5.80 | −16.00 |
| AUC0–inf (µg·h/mL) | 13.35 | 56.60 | −323.97 | 15.00 | −12.36 |