Table 7.
Glide docking score.
| Ligands | NR1-2A | NR1-2B | NR1-2C | NR1-2D | ||||
|---|---|---|---|---|---|---|---|---|
| Template 6WHS |
Template 6WHT | Template 6WHS |
Template 6WHT | Template 6WHS |
Template 6WHT | Template 6WHS |
Template 6WHT | |
| REL-1017 | −6.5 | −8.0 | −6.7 | −8.0 | −6.7 | −8.1 | −6.4 | −8.1 |
| MK-801 | −7.0 | −7.0 | −7.2 | −6.7 | −7.1 | −6.7 | −7.1 | −6.7 |
| Arketamine | −6.1 | −6.6 | −7.0 | −6.6 | −6.2 | −6.6 | −6.3 | −6.6 |
| Esketamine | −6.1 | −6.5 | −6.4 | −6.5 | −6.0 | −6.0 | −6.0 | −6.0 |
The Glide docking score (kcal/mol) of some of the investigated ligands at the NMDAR model of closed (6WHS) and open (6WHT) channel conformation.