FIG. 1.

Dendrogram of approximate sequence relationships among DHPSs from M. tuberculosis (this work), M. leprae (this work), E. coli (11), S. aureus (14), S. haemolyticus (16), Bacillus subtilis (32), S. pneumoniae (19), and N. meningitidis (25) and DHPS domains of polyproteins from P. carinii (38), P. falciparum (5, 35), and T. gondii (23). (Failure to match accepted phylogenetic branching order can be seen in certain cases, in particular where a species with an expected history of relatively rapid evolutionary change is involved, such as P. falciparum.)