Table 3.

Summarization of the studies in which the authors sequenced the 16S rRNA in rats.

Model	Hypervariable Regions	Sequencer	Microbiota Changes	Reference
Wistar, Sprague-Dawley	V3–V4	MiSeq PE300	Proteobacteria ↑ Firmicutes ↑ Firmicutes/Bacteroidetes ratio ↑ Oscillospira ↑ Peptostreptococcaceae ↑ Mycoplasma ↑ Roseburia ↑ Clostridiaceae ↑ Sutterella ↑ Clostridiales ↑ RF32 ↑ Christensenellaceae ↑ Blautia ↑ rc4-4 ↑ Prevotella ↓ Actinomyces ↑ Arthrobacter ↑ Porphyromonas ↑ Bacteroides ↓	[40]
Sprague-Dawley	V3–V4	MiSeq	Bacteroides ↑ Prevotella_1 ↑	[41]
Sprague-Dawley	V4	HiSeq 2500	Bacteroidetes ↑ Prevotella ↑ Prevotella copri ↑	[42]
Sprague-Dawley	338F–806R primers	-	SMB53 ↑↓ p-75-a5 ↑↓ rc4–4 ↑ Phascolarctobacterium ↑ Veillonella ↑ Anaerostipes ↑ Desulfovibrio ↓ Corynebacterium ↓ Trichococcus ↑ Lachnobacterium ↑ Epulopiscium ↑ Allobaculum ↓
Sprague-Dawley	V4	HiSeq 2000	-	[44]

↑—increase; ↓—decrease; ↑↓—variations rely on the study design/patient allocations.