Table 4.
Summarization of the studies in which the authors sequenced the 16S rRNA in mice.
| Model | Hypervariable Region | Sequencer | Microbiota Changes | Reference |
|---|---|---|---|---|
| C57BL/6 | V3–V4 | HiSeq 4000 |
Bacteroidetes ↓ Verrucomicrobia ↓ Firmicutes ↑ Proteobacteria ↑ |
[45] |
| C57BL/6J | V4 | MiSeq |
Corynebacterium ↑ Rikenellaceae ↑ |
[46] |
| C57BL/6J | V3–V4 | HiSeq 6000 |
Verrucomicrobiae ↑ Gammaproteobacteria ↑ Mollicutes ↑ Bacteroidia ↓ Betaproteobacteria ↓ |
[47] |
| KK-Ay C57BL/6J | V3–V4 | MiSeq |
Weissella confusa ↓ Clostridium sp. ND2 ↓ Anaerotruncus colihominis DSM 17,241 ↓ [Clostridium] leptum ↓ |
[49] |
| KK-Ay C57BL/6 | V3–V4 | MiSeq |
Bacteroidales S24-7 group ↑ Bifidobacterium ↑ Akkermansia ↑ |
[50] |
| CD-1 | V3–V4 | HiSeqTM 2500 | Lactobacillus ↑ | [51] |
| C57BL/6 | V4 | MiSeq |
Bacteroidetes ↓ Firmicutes ↑ Deferribacteres ↑ |
[52] |
| ICR | V3–V4 | HiSeq X Ten |
Lactobacillaceae ↑ Desulfovibrionaceae ↓ Proteobacteria ↑ Bacteroidales ↑ |
[53] |
| BALB/c | V3–V4 | MiSeq |
Lachnospiraceae ↑ Ruminococcaceae ↑ Christensenellaceae ↑ Lactobacillus ↑ |
[54] |
| C57BL/6J | V3–V4 | MiSeq |
Candidatus Saccharimonas ↑↓ Ruminococcus1 ↑↓ Helicobacter ↑↓ Anaeroplasma ↑↓ |
[55] |
↑—increase; ↓—decrease; ↑↓—variations rely on the study design/patient allocations.