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. 2022 Jul 29;12(8):710. doi: 10.3390/metabo12080710

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Metabolism of [2,4-¹³C]β-hydroxybutyrate (¹³C-BHB) in the brain. (A). Labeling pattern from the metabolism of [2,4-¹³C]β-hydroxybutyrate (¹³C-BHB). (B). Typical ¹³C-NMR spectra of rat brain after the infusion of 0.2 M [2,4-¹³C]β-hydroxybutyrate (¹³C-BHB). Peak assignment: (1) lactate C3; (2) BHB C4; (3) N-acetylaspartate C6; (4) GABA C3; (5) Gln C3; (6) Glu C3; (7) Gln C4; (8) Glu C4; (9) GABA C2; (10) aspartate C3; (11) GABA C4; (12) BHB C2; (13) aspartate C2; (14) Gln C2; (15) Glu C2. Abbreviations: glutamate = Glu; glutamine = Gln; BHB = β-hydroxybutyrate.