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. 2022 Aug 9;27(16):5065. doi: 10.3390/molecules27165065

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Gross appearance of gastric mucosa in rats: (A) treated with saline 10 mL/kg. (B) Severe lesions are observed with absolute ethanol (1 mL/100g) treatment along with hemorrhagic necrosis of gastric mucosa. (C–E): MBO treatment groups at doses of 5 mg/kg, 10 mg/kg and 30 mg/kg, respectively. (F) Pre-treated with omeprazole (30 mg/kg). The gastric lesions were reduced with increased doses of MBO and omeprazole compared to ulcer control. At 30 mg/kg, MBO showed the most effective gastro-protective action.