HPV-negative oral papilloma (a,b) and HPV-positive papilloma (c,d). (a) Macroscopically, tumor lesion located at the jugal mucosa, round shape, size 0.75 mm, pinkish-whitish color, poorly vascularized, non-bleeding; (b) Histological aspect of jugal mucosa; acanthosis, parakeratosis and koilocytes presence in the epithelium, (trichrome stain × 200); (c) Macroscopically, tumor lesion located at the occlusal line of the jugal mucosa, round-oval shape, size 0.95 mm, red color, richly vascularized, bleeding at the slightest trauma; (d) Hiper- and parakeratosis, acanthosis and koilocytes presence in the epithelium; in the basal epithelial layer mitotic figures are present. Proinflammatory cells infiltrate the mucosa (trichrome stain × 400).