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. 2022 Aug 26;45(12):2385–2403. doi: 10.1007/s40618-022-01859-7

Table 1.

Main factors associated with an increase or with a reduction of Sex hormone binding globulin (SHBG) circulating levels

SHBG increase

- Drugs: anticonvulsant, estrogens, thyroid hormone, antiretroviral drugs

- Hyperthyroidism

- HIV disease

- Cirrhosis and hepatitis

- Aging

SHBG decrease

-Drugs: GH, glucocorticoids, testosterone, Anabolic androgenic steroids

-Hypothyroidism

-Obesity

-Acromegaly

-Cushing Disease

-Insulin resistance

-Nephrotic syndrome