Table 3.

Summary of testosterone replacement therapy (TRT) outcomes

TRT outcomes	Outcome evaluation
Sexual function
Erectile dysfunction	↑ ⊕  ⊕
Libido	↑ ⊕  ⊕  ⊕
Ejaculation	↑ ⊕
TRT + PDE5i
Erectile dysfunction	↔
Body composition
Fat mass	↓ ⊕
Lean mass	↑ ⊕
Body mass index	↔
Waist	↔
Metabolic control
Glucose metabolism	↑ ⊕
Lipid profile	↑ ⊕  ↔
Blood pressure	↔
Bone
Bone mass	↑ ⊕
Fracture risk	NA
Mood/cognition
Depressive symptoms	↑ ⊕
Cognition	NA
Mobility
	↑ ⊕

 ⊕  = arbitrary unit indicating: ⊕  = mild ⊕  ⊕  = moderate, ⊕  ⊕  ⊕  = strong effect. ↑ = positive effect ↓ = negative effect ↔  = neutral effect. NA = not available; PDE5i, phosphodiesterase type 5 inhibitors