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. 2022 Aug 26;18(10):579–596. doi: 10.1038/s41582-022-00698-7

Table 1.

Features of delirium and dementia

Feature Delirium Dementia due to Alzheimer disease Frontotemporal lobe dementia Diffuse Lewy body disease Vascular dementia
Descriptive features Inattention, impairment of immediate memory Memory impairments, plus impairments in multiple other cognitive domains Behavioural disorder, mental rigidity, distractibility Fluctuating cognition with variations in attention and alertness Abrupt deterioration or stepwise progression of cognitive deficits; mood and personality changes
Onset Acute, episodic Insidious Insidious Insidious Insidious, abrupt or stepwise
Duration Hours to months Months to years Months to years Months to years Months to years
Course Fluctuating, might be worse at night and on waking Chronic, progressive Chronic, progressive Chronic, progressive Chronic, progressive
Alertness Altered Normal Normal Fluctuates Normal
Reversibility Usually No No No No
Attention Impaired by definition Usually, normal, but might be impaired in later stages Might be persistently impaired and early feature Fluctuates Might be persistently impaired and early feature
Orientation Fluctuates Not oriented Typically intact Variable Variable
Speech Incoherent speech Word-finding difficulties Altered speech output; stereotypy of speech; echolalia; perseveration; mutism Hypophonic speech
Thought Disorganized and disconnected thoughts, for example, ‘flight of ideas’ Difficulty with abstract thinking Poor judgement; impulsivity Abnormal executive function, including mental rigidity and poor insight and judgment
Perception Distorted: illusions, delusions and/or hallucinations (often visual, tactile or poorly formed) Delusions of theft or persecution, more common in later stages; hallucinations (auditory, distinct) uncommon Delusions might be paranoid, religious or bizarre in nature Visual hallucinations are recurrent and typically well-formed and detailed (that is, animals or children); delusions are common Delusions more common in later stages
Psychomotor changes Frequent Inconsistent Hyperorality; utilization behaviour Parkinsonism Psychomotor retardation
Agitation Occurs with delirium symptoms, throughout the day Might occur with sundowning or when resisting activities of daily living Common Variable Variable
Sleep–wake cycle Often reversed Might be fragmented but circadian rhythmicity retained Severely fragmented REM sleep behaviour disorder Sleep disturbances are common