Skip to main content
. 2022 Aug 18;14(16):3395. doi: 10.3390/nu14163395

Figure 1.

Figure 1

Irradiation-induced myelosuppression accompanies Pi loss in BM niche and Pi metabolic inhibition in HSCs. (A) Scheme for the mouse model of irradiation-induced myelosuppression and the analysis of cell counts, HSC survival, and Pi metabolism in peripheral blood (PB) and/or BM. (B–D) White blood cell (WBC), red blood cell (RBC), and platelet counts in PB of mice post IR (n = 6). (E) BMC counts post IR (n = 6). (F) HSC numbers in the BM of mice post IR (n = 6). (G) Representative flow cytometric analysis and quantification of apoptotic HSCs in the BM of mice at 3 dpi (n = 6). (H–J) Pi contents in serum, BM niche, and LSK cells of mice post IR (n = 6). (K) GSEA of apoptosis gene set in HSCs with enhanced Pi metabolism (PRJNA695319). Data are mean ± SD. * p < 0.05, ** p < 0.01. Two-tailed unpaired Student’s t-test.