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. 2022 Aug 18;14(16):3395. doi: 10.3390/nu14163395

Figure 3.

Figure 3

Enhancement of Pi metabolism by Klotho deficiency promotes HSC survival post IR. (A) Scheme for the creation of mouse model of irradiation-induced myelosuppression using Kl+/− mice and HSC analysis. (B) Pi content in BM LSK cells of WT and Kl+/− mice post IR (n = 6). (C) Relative HSC numbers in the BM of WT and Kl+/− mice post IR compared to those at 0 dpi (n = 6). (D) Representative flow cytometric analysis and quantification of apoptotic HSCs in the BM of WT and Kl+/− mice at 3 dpi (n = 6). (E–G) WBC, RBC, and platelet counts in PB of WT and Kl+/− mice post IR (n = 6). Data are mean ± SD. * p < 0.05, ** p < 0.01. Two-tailed unpaired Student’s t-test.