Skip to main content
. 2022 Aug 18;14(16):3395. doi: 10.3390/nu14163395

Figure 7.

Figure 7

p53 transcriptionally restrains SLC20A1-mediated Pi uptake of HSCs. (A) Fold change of SLC20A1 MFI in BM HSCs of WT and p53−/− mice without IR exposure (n = 5). (B) Pi content in BM LSK cells of WT and p53−/− mice without IR exposure (n = 6). (C) Pi content in BM LSK cells of WT and p53−/− mice post IR (n = 6). (D) Fold change of SLC20A1 MFI in BM HSCs of WT and p53−/− mice at 3 dpi (n = 5). (E) The putative p53 binding site in the promoter of Slc20a1 gene as predicted by both JASPAR and AnimalTFDB 3.0. (F) ChIP assay of p53 binding to the Slc20a1 promoter sequence post IR (n = 3). Data are mean ± SD. ns = not significant. * p < 0.05, ** p < 0.01. Two-tailed unpaired Student’s t-test.