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. 2022 Aug 18;14(16):3395. doi: 10.3390/nu14163395

Figure 8.

Figure 8

Pi supplementation promotes HSC survival and protects against irradiation-induced myelosuppression. (A) Scheme for HPD treatment and HSC analysis. (B) Pi content in BM LSK cells of mice with CD or HPD post IR (n = 6). (C) Representative flow cytometric analysis and fold change of p-AktS473 MFI in BM HSCs of mice with CD or HPD at 3 dpi (n = 5). (D) Representative flow cytometric analysis and fold change of p53 MFI in BM HSCs of mice with CD or HPD at 3 dpi (n = 5). (E) Representative flow cytometric analysis and quantification of apoptotic HSCs in the BM of mice with CD or HPD at 3 dpi (n = 6). (F) Relative HSC numbers in the BM of mice with CD or HPD post IR compared to those at 0 dpi (n = 6). (G–I) WBC, RBC, and platelet counts in PB of mice with CD or HPD post IR (n = 6). Data are mean ± SD. * p < 0.05, ** p < 0.01. Two-tailed unpaired Student’s t-test.