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. 2022 Aug 15;11(16):2120. doi: 10.3390/plants11162120

Figure 3.

Figure 3

Common features pharmacophore of 14-α-demethylase enzyme substrates and TNS. (A) 3D pharmacophore generated from 14-α-demethylase enzyme substrates lanosterol, eburicol, and obtusifoliol. Cyano spheres represent hydrophobic features. Green spheres represent hydrogen bond acceptor features. Lines represent distance in Angstrom. (B) 2D and 3D diagram showing lanosterol alignment and feature mapping to generate a pharmacophore. (C) 2D and 3D diagram showing eburicol alignment and feature mapping to generate a pharmacophore. (D) 2D and 3D diagram showing obtusifoliol alignment and feature mapping to generate a pharmacophore. (E) 2D and 3D diagram showing TNS alignment and feature mapping to generate a pharmacophore.