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. 2022 Aug 13;14(8):1689. doi: 10.3390/pharmaceutics14081689

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Transepidermal water loss (TEWL) as the indicator of dermal barrier function, determined in (1) rat skin samples after 10 tape strippings before any kind of treatment or after 5h exposition to 2% caffeine or quinidine cream in the skin-on-a-chip device; (2) in EpiDerm^TM HRE tissues before any kind of treatment or after 5 h exposition to 2% caffeine or quinidine cream in the skin-on-a-chip device. N = 11 for the skin before, and N = 3−4 for the other groups. Data are expressed as means ± SEM.