Table 3.

GRADE table for this meta-analysis.

Quality of Evidence	Low	Moderate	Moderate	Low	Low	Moderate	Low	Very Low
Dose effect	NA	NA	NA	NA	NA	NA	NA	NA
Effect size	Moderate	Moderate	Moderate	Small	Small	Moderate	NA	Small
Publication bias	√	√	√	√	√	√	√	√
Imprecision	√	√	√	√	√	√	√	√
Indirectness	√	√	√	√	√	√	√	√
Inconsistency	√	√	√	√	√	√	√	√
Risk of bias	×	√	√	√	√	√	√	×
Study design	Cases	Retrospective	Retrospective	Retrospective	Non-randomized clinical trial	Non-randomized clinical trial	Non-randomized clinical trial	Retrospective
Study	Peterson et al. 2020 [25]	Ronsley et al. 2021 [32]	Selt et al. 2020 [33]	Toledano et al. 2021 [34]	McCowage et al. 2018 [35]	Manoharan et al. 2020 [36]	Geoerger et al. 2018 [37]	Paul et al. 2020 [38]

√ indicates no serious limitations; ×, serious limitations; effect size—objective response rate (ORR) ≥ 0.5 for moderate effect or ORR ≥ 0.8 for large effect; NA, not applicable.